CCR Gulbenkian

Cell Cycle Regulation Lab

We study the regulation of cell proliferation with an emphasis on centrioles and cilia. Centrioles are essential for the formation of several microtubule-organizing structures, including centrosomes, cilia, and flagella. Centrosomes are the major microtubule organizer in animal cells, while cilia and flagella are important in signalling and motility. Centriole abnormalities have been observed in a variety of human diseases and understanding the pathways involved in their regulation is invaluable to generate diagnostic and prognostic markers, and provide novel therapeutic targets. We use an integrated approach that combines studies in model organisms and in human cells, with bioinformatics and mathematical modelling.