Centrosome and cilia alterations, in particular the presence of multiple centrioles, can lead to abnormalities in chromosome segregation, asymmetric cell divisions, invasiveness and ability to induce cancer in mice.

Multiple questions remain, in particular how those changes originate, how they contribute to cancer and how can they be taken advantage off for translational purposes. We use different experimental systems to tackle those questions.

We have dissected when centrosome abnormalities arise in tumor progression (Lopes et al, JCB, 2018), and uncovered that the over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation (Marteil et al, Nature Comm, 2018). Using cancer cell lines, including the NCI-60 panel of human cancer cell lines derived from 9 distinct tissues, we continue to address the highlighted questions combined with bioinformatics and modelling of centriole number along tumor progression.