Do you like our knitted chromosomes? More info here.
Welcome to the chromosome dynamics lab
The Chromosome Dynamics Lab, at Instituto Gulbenkian de Ciência, studies how chromosome architecture contributes to faithful genome segregation. Genome stability relies on the fact that at each round of cell division, the genetic information encoded in the DNA molecules is properly segregated into the two daughter cells. Proper completion of this process, in turn, depends on major changes in chromosome organisation including cohesion between the two identical DNA molecules (sister chromatids) and condensation of the long DNA fibbers. We aim to dissect how mitotic chromosomes are assembled and how their physical properties contribute to faithful cell division.
By studying the contribution of chromosome structure in the mechanics of nuclear division we aim to identify novel routes to aneuploidy that underlie several human conditions, including developmental diseases, cancer and infertility.
Read more about our research.
Here is a short video introducing Raquel Oliveira and the research in the lab. From the series #MeetIGCScientists produced by the IGC communication team.
see also CHR in the news
We have just been awarded an ERC consolidator Grant to study transcriptional inactivation in mitosis. Check more on our institutional press release .
AND WE ARE RECRUITING!!!! CHECK THE AD FOR 2 POST DOC POSITIONS!!!
Fruitful collaboration with Diogo Castro on the hierarchy of gene reactivation upon mitotic exit is now published in Genes & Development!
Our former Post-doc Sara Carvalhal just started a Junior Group Leader Position at the University of Algarve. Her group will be studying mitotic fidelity in rare diseases. Check more at Carvalhal Lab Webpage.
Check our "paper video" produced by the IGC Outreach team about our eLife paper on how condensins guide topoisomerase 2 action: