Welcome to the chromosome dynamics labThe Chromosome Dynamics Lab, at Instituto Gulbenkian de Ciência, studies how chromosome architecture contributes to faithful genome segregation. Genome stability relies on the fact that at each round of cell division, the genetic information encoded in the DNA molecules is properly segregated into the two daughter cells. Proper completion of this process, in turn, depends on major changes in chromosome organisation including cohesion between the two identical DNA molecules (sister chromatids) and condensation of the long DNA fibbers. We aim to dissect how mitotic chromosomes are assembled and how their physical properties contribute to faithful cell division.
By studying the contribution of chromosome structure in the mechanics of nuclear division we aim to identify novel routes to aneuploidy that underlie several human conditions, including developmental diseases, cancer and infertility. Read more about our research. Check our latest "paper video" produced by the IGC Outreach team about our recent paper in eLife:
Here is a video summarising the research at the Oliveira lab, produced by EMBO.
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LATEST NEWSsee also CHR in the news
Amazing team effort from Mihailo Mirkovic and Gaston Guilgur on the consequences of aneuploidy. Check more at Plos Biology.
Absence of the Spindle Assembly Checkpoint can rescue cohesion defects. Amazing findings arising from a fruitful collaboration with Rui Martinho's lab, at Universidade do Algarve. Out at Current Biology.
Quantitative analysis of cohesin decay. Great effort from Sara Carvalhal and many others from the CHR team. See it at Journal of Cell Biology.
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