Our Publications


Gouveia SM, Zitouni S, Kong D, Duarte P, Gomes BF, Sousa AL, Tranfield EM, Hyman A, Loncarek J, Bettencourt-Dias M. . PLK4 is a microtubule-associated protein that self assembles promoting de novo MTOC formation. J. CELL SCIENCE. more

Jana SC, Mendonça S, Machado P, Werner S, Rocha J, Pereira A, Maiato H, Bettencourt-Dias M. . Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity. NATURE CELL BIOLOGY. more

Ito D, Bettencourt-Dias M.. Centrosome Remodelling in Evolution. CELLS. more

Daisuke Ito, Sihem Zitouni, Swadhin Chandra Jana, Paulo Duarte, Jaroslaw Surkont, Zita Carvalho-Santos, Jose B. Pereira-Leal, Miguel Godinho Ferreira, Monica Bettencourt-Dias An ancestral role of pericentrin in centriole formation through SAS-6 recruitmentbioRxiv

Lopes CAM, Mesquita M, Cunha AI, Cardoso J, Carapeta S, Laranjeira C, Pinto AE, Pereira-Leal JB, Dias-Pereira A, Bettencourt-Dias M, Chaves P. Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis.. J CELL BIOLOGY. link

Nabais C, Pereira SG, Bettencourt-Dias M. Noncanonical Biogenesis of Centrioles and Basal Bodies.. COLD SPRING HARB SYMP QUANT BIOL. link

Marteil G, Guerrero A, Vieira AF, de Almeida BP, Machado P, Mendonça S, Mesquita M, Villarreal B, Fonseca I, Francia ME, Dores K, Martins NP, Jana SC, Tranfield EM, Barbosa-Morais NL, Paredes J, Pellman D, Godinho SA, Bettencourt-Dias M.Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation.. NATURE COMMUNICATIONS. link

Loncarek J, Bettencourt-Dias M. Building the right centriole for each cell type. J CELL


Marteil G, Dias Louro MA, Bettencourt-Dias M. Centrosome Assembly: Reconstructing the Core Cartwheel Structure In Vitro. CURRENT BIOLOGY


Cardoso J, Mesquita M, Dias Pereira A, Bettencourt-Dias M, Chaves P, Pereira-Leal JB. CYR61 and TAZ Upregulation and Focal Epithelial to Mesenchymal Transition May Be Early Predictors of Barrett's Esophagus Malignant Progression. PLoS One.

Jana SC, Mendonça S, Werner S, Bettencourt-Dias M. Methods to Study Centrosomes and Cilia in Drosophila. METHODS IN MOLECULAR BIOLOGY

Pimenta-Marques A, Bento I, Lopes CA, Duarte P, Jana SC, Bettencourt-Dias M. A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster. SCIENCE

Zitouni S, Francia ME, Leal F, Montenegro Gouveia S, Nabais C, Duarte P, Gilberto S, Brito D, Moyer T, Kandels-Lewis S, Ohta M, Kitagawa D, Holland AJ, Karsenti E, Lorca T, Lince-Faria M, Bettencourt-Dias M. CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis. CURRENT BIOLOGY.


Chen JV, Kao LR, Jana SC, Sivan-Loukianova E, Mendonça S, Cabrera OA, Singh P, Cabernard C, Eberl DF, Bettencourt-Dias M, Megraw TL. Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila. J CELL BIOLOGY.

Lopes C, Jana SC, Cunha-Ferreira I, Zitouni S, Bento I, Duarte P, Gilberto S, Freixo F, Guerrero A, Francia M, Lince-Faria M, Carneiro J, Bettencourt-Dias M. PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space. DEVELOPMENTAL CELL. more


Zitouni S, Nabais C, Jana SC, Guerrero A, Bettencourt-Dias M. Polo-like kinases: structural variations lead to multiple functions. NAT REV MOL CELL BIOL. more

Jana SC, Marteil G, Bettencourt-Dias M. Mapping molecules to structure: unveiling secrets of centriole and cilia assembly with near-atomic resolution. CURR OPIN CELL BIOL. more


Cunha-Ferreira I, Bento I, Pimenta-Marques A, Jana SC, Lince-Faria M, Duarte P, Borrego-Pinto J, Gilberto S, Amado T, Brito D, Rodrigues-Martins A, Debski J, Dzhindzhev N, Bettencourt-Dias M. Regulation of autophosphorylation controls PLK4 self-destruction and centriole number. CURR BIOL. more

Bettencourt-Dias M. Q&A: Who needs a centrosome?. BMC Biol. more


Jana SC, Bazan JF, Bettencourt-Dias M. Polo boxes come out of the crypt: a new view of PLK function and evolution. STRUCTURE more

Carvalho-Santos Z, Machado P, Alvarez-Martins I, Gouveia SM, Jana SC, Duarte P, Amado T, Branco P, Freitas MC, Silva ST, Antony C, Bandeiras TM, Bettencourt-Dias M. BLD10/CEP135 is a microtubule-associated protein that controls the formation of the flagellum central microtubule pair. DEVELOPMENTAL CELL. more

Holland AJ, Fachinetti D, Da Cruz S, Zhu Q, Vitre B, Lince-Faria M, Chen D, Parish N, Verma IM, Bettencourt-Dias M, Cleveland DW. Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. MOLECULAR BIOLOGY OF THE CELL. more

Brito DA, Gouveia SM, Bettencourt-Dias M. Deconstructing the centriole: structure and number control. CURR OPIN CELL BIOL. more

Jana SC, Machado P, Bettencourt-Dias M. A structural road map to unveil basal body composition and assembly. EMBO JOURNAL. more

Bettencourt-Dias M, Hildebrandt F, Pellman D, Woods G, Godinho SA. Centrosomes and cilia in human disease.


Carvalho-Santos Z, Azimzadeh J, Pereira-Leal JB, Bettencourt-Dias M. Evolution: Tracing the origins of centrioles, cilia, and flagella. J Cell Biol. more

Bettencourt-Dias M, Hildebrandt F, Pellman D, Woods G, Godinho SA. Centrosomes and cilia in human disease. Trends Genet. more


Dzhindzhev NS, Yu QD, Weiskopf K, Tzolovsky G, Cunha-Ferreira I, Riparbelli M, Rodrigues-Martins A, Bettencourt-Dias M, Callaini G, Glover DM. Asterless is a scaffold for the onset of centriole assembly. NATURE. more

Otto EA, Hurd TW, Airik R, Chaki M, Zhou W, Stoetzel C, Patil SB, Levy S, Ghosh AK, Murga-Zamalloa CA, van Reeuwijk J, Letteboer SJ, Sang L, Giles RH, Liu Q, Coene KL, Estrada-Cuzcano A, Collin RW, McLaughlin HM, Held S, Kasanuki JM, Ramaswami G, Conte J, Lopez I, Washburn J, Macdonald J, Hu J, Yamashita Y, Maher ER, Guay-Woodford LM, Neumann HP, Obermüller N, Koenekoop RK, Bergmann C, Bei X, Lewis RA, Katsanis N, Lopes V, Williams DS, Lyons RH, Dang CV, Brito DA, Dias MB, Zhang X, Cavalcoli JD, Nürnberg G, Nürnberg P, Pierce EA, Jackson PK, Antignac C, Saunier S, Roepman R, Dollfus H, Khanna H, Hildebrandt F. Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nat Genet. more

Bettencourt-Dias M. Mónica Bettencourt-Dias: centered on centrioles. Interview by Ben Short. J CELL BIOL. more

Martins AR, Machado P, Callaini G, Bettencourt-Dias M. Microscopy methods for the study of centriole biogenesis and function in Drosophila. METHODS CELL BIOL. Review.

Carvalho-Santos Z, Machado P, Branco P, Tavares-Cadete F, Rodrigues-Martins A, Pereira-Leal JB, Bettencourt-Dias M. Stepwise evolution of the centriole-assembly pathway. J CELL SCIENCE. more

Debec A, Sullivan W, Bettencourt-Dias M. Centrioles: active players or passengers during mitosis? CELL Mol Life Sci. more


Bettencourt-Dias M, Goshima G. RNAi in Drosophila S2 cells as a tool for studying cell cycle progression. METHODS MOL BIOL. more

Kuriyama R, Bettencourt-Dias M, Hoffmann I, Arnold M, Sandvig L. Gamma-tubulin-containing abnormal centrioles are induced by insufficient Plk4 in human HCT116 colorectal cancer cells. J CELL SCIENCE. more

Cunha-Ferreira I, Bento I, Bettencourt-Dias M. From zero to many: control of centriole number in development and disease. TRAFFIC. more

Bettencourt-Dias M, Glover DM. SnapShot: centriole biogenesis. CELL. more

Cunha-Ferreira I, Rodrigues-Martins A, Bento I, Riparbelli M, Zhang W, Laue E, Callaini G, Glover DM, Bettencourt-Dias M. The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4. CURRENT BIOL. more


See our Award Feature on Centrosomes in Nature (more).

Rodrigues-Martins A, Riparbelli M, Callaini G, Glover DM, Bettencourt-Dias M. From centriole biogenesis to cellular function: centrioles are essential for cell division at critical developmental stages. CELL CYCLE. more

Bettencourt-Dias M, Carvalho-Santos Z. Double life of centrioles: CP110 in the spotlight. TRENDS CELL BIOLOGY. more


Rodrigues-Martins A, Bettencourt-Dias M, Riparbelli M*, Ferreira C, Ferreira I, Callaini G, Glover DM. DSAS-6 organizes a tube-like centriole precursor, and its absence suggests modularity in centriole assembly. CURRET BIOLOGY more

Bettencourt-Dias M, Glover DM. Centrosome biogenesis and function: centrosomics brings new understanding. NAT REV MOL CELL BIOL. more

Rodrigues-Martins A, Riparbelli M, Callaini G, Glover DM, Bettencourt-Dias M. Revisiting the role of the mother centriole in centriole biogenesis. SCIENCE. more
Recommended by Faculty of 1000 Biology (here)


Bettencourt-Dias M, Rodrigues-Martins A, Carpenter L, Riparbelli M, Lehmann L, Gatt MK, Carmo N, Balloux F, Callaini G, Glover DM. SAK/PLK4 is required for centriole duplication and flagella development. CURRENT BIOLOGY. more


Bettencourt-Dias M, Giet R, Sinka R, Mazumdar A, Lock WG, Balloux F, Zafiropoulos PJ, Yamaguchi S, Winter S, Carthew RW, Cooper M, Jones D, Frenz L, Glover DM. Genome-wide survey of protein kinases required for cell cycle progression. NATURE. more
Selected as a MUST READ paper by Faculty of 1000 Biology (here).


Bettencourt-Dias M, Mittnacht S, Brockes JP. Heterogeneous proliferative potential in regenerative adult newt cardiomyocytes. J CELL SCIENCE. more


Martins AR, Machado P, Callaini G, Bettencourt-Dias M. (2010). Microscopy methods for the study of centriole biogenesis and function in Drosophila. Methods Cell Biol. more

Bettencourt-Dias M, Sinka R, Frenz L, Glover DM. (2004). RNAi in Drosophila cell cultures. In Gene Silencing by RNA Interference: Technology and Application, Ed. Sohail M. CRC Press. pp.147-165