The Cell Cycle Regulation Laboratory

About Us

Our Work

Image We study the regulation of cell proliferation with an emphasis on centrioles and cilia. Centrioles are essential for the formation of several microtubule-organizing structures, including centrosomes, cilia, and flagella. Centrosomes are the major microtubule organizer in animal cells, while cilia and flagella are important in signalling and motility. Abnormalities in microtubule-organising structures and cell polarity have been observed in a variety of human diseases, such as cancer and cystic kidneys. An understanding of the pathways involved in the regulation of microtubule-organising centers formation and cell proliferation will be invaluable to generate diagnostic and prognostic markers, and provide novel therapeutic targets.

Our Approach

ImageOurs is an integrated approach that combines studies in model organisms and in human cells, with bioinformatics and mathematical modelling. The fruit fly is ameanable to multiple gene screening as well as to in-depth regulation studies at the organism level. As cell proliferation mechanisms are highly conserved throughout evolution, we can extrapolate our findings from the fruit fly to humans, and test the relevance of the data in human disease development. We collaborate with a variety of in-house groups, and also with labs in the UK, Italy, Germany, France, and US, in order to complement our own expertise, and to strengthen and accelerate the work. Check our papers and projects to learn more!

Timeline


PRESENT - 2017

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PAST
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2006 - CCR was Born!

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