Welcome to our website
About Us
Our Work
We study the regulation of cell proliferation with an emphasis on polarity
and centrioles. Centrioles are essential for the formation of several
microtubule -organizing structures, including centrosomes, cilia and flagella.
more
Our Approach
An integrated approach combining studies in model organisms with studies
in human cells, bioinformatics and mathematical modelling. more
Our Research
Centrosome Biogenesis & Function
Centrioles
are essential for the formation of several microtubule (MT) - organizing
structures including centrosomes, cilia and flagella. In the centrosome,
two centrioles associate with the pericentriolar matrix (PCM), constituting
the primary microtubule organizing centre in animal cells. more
Polarity and Cell Cycle Progression
The loss
of epithelial polarity and tissue architecture is a primary diagnostic
mark of malignant carcinomas. The relationship between loss of epithelial organization
and progression toward malignancy in mammalian tumors has long been known, but
whether this is merely correlative or whether loss of architecture might have
some causative contribution to tumorigenesis, specifically by affecting cell
cycle progression, remains an important question. more
The Team
There
are nine of us in The Cell Cycle Regulation Lab: the PI, five PhD students, one Post-Doc
and one research assistant. Each of us works on a different, but complementary
project. Currently the group encompasses biologists,
biochemists, chemists, cytologists and biological engineers but we welcome people from other
backgrounds, such as physics and informatics. more
News
2009 Schlumberger Grant to our Lab
New papers from our Group:
-
Cunha-Ferreira I, Bento I, Bettencourt-Dias M.
From Zero to Many: Control of Centriole Number in Development and Disease. Traffic. 2009; 10(5):482-98.
more
- Bettencourt-Dias and Goshima RNAi in Drosophila S2 Cells as a Tool for Studying Cell Cycle Progression. Methods Mol Biol. 2009;545:39-62.more
- Bettencourt-Dias and Glover SnapShot: centriole biogenesis. Cell. 2009; 136(1):188-188.e1. more
- Cunha-Ferreira I, Rodrigues-Martins A, Bento I, Riparbelli M, Zhang W, Laue E, Callaini G, Glover DM, Bettencourt-Dias M. The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4. Curr Biol. 2009; 19(1):43-9. more
See our Award Feature on Centrosomes in Nature more
Lab Outing Photos more
New opportunities in our Group more